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RETIN-A (tretinoin)  

RENOVA (tretinoin emollient cream)  

RETIN-A (tretinoin)

HOW DOES RETIN-A WORK?

    Evidence suggests that RETIN-A acts primarily by modifying the abnormal keratinization (formation of the superficial layer of skin) located around hair follicles. Comedones (large deep seeded pus filled pimples) form in follicles with an excess of keratinized superficial skin cells. RETIN-A promotes the detachment of these excess cells and the enhanced shedding of these cells from the follicular base. Through this action, comedo contents are emptied and the formation of new comedones is significantly reduced.


HOW TO USE THIS MEDICATION?
   Apply a thin layer to affected areas at bedtime. Use a gauze pad or cotton swab to apply the liquid. Wash your hands immediately after use. Using this medication more frequently or in excessive amounts does not improve the results, but may increase side effects. Avoid applying near the eyes, mouth, or open cuts since this medication can irritate sensitive skin. Acne may appear to worsen when the medication is first used; continue therapy. It may take three to six weeks before the full benefits of this medication are seen.

HOW EFFECTIVE IS RETIN-A?
   In a number of different clinical studies RETIN-A was significantly superior to a control gel in decreasing comedo count. Taken together approximately 25% of patients achieved superior results with the use of this medication.

CAN I USECOSMETICS IF I AM ALSO USING RETIN-A?
   Cosmetics may be used, but clean skin thoroughly before applying RETIN-A.

USE DURING PREGNANCY:
   RETIN-A is applied to the skin. Usually, less than 10% of RETIN-A passes into the mother's bloodstream, and even less reaches the baby. Broken skin, using more than is needed on an area, or use on a large area will cause more of the RETIN-A to pass through the skin. In general, the less RETIN-A that is used on the mother's skin, the less likely there will be risks to the baby.
   Several studies have tried to find out the effects of RETIN-A on pregnancy. These studies have not found that babies whose mothers used RETIN-A during pregnancy are any more likely to have birth defects than babies whose mothers did not use RETIN-A.
   Nonetheless, it may be best to reserve RETIN-A use during pregnancy for only the most severe cases of Acne Vulgaris. Even then, it should be used with extreme caution.

SIDE EFFECTS:
   Immediately after applying, the skin may feel warm or mild stinging or redness may occur. Some peeling of the skin may occur. These effects should subside as your skin adjusts to the medication. If they persist or become bothersome, stop the medication. This medicine may also increase sun sensitivity. RETIN-A may also cause itchiness and scaling of the skin. This can sometimes be very extreme depending on the individual. Most people will experience some itching or scaling if too much RETIN-A is applied.

CAUTIONS:
   This medication can increase sensitivity to sunlight, wind and cold. Avoid prolonged exposure to the sun and sunlamps. Wear protective clothing and use an effective sunscreen. This medication should be used during pregnancy only if clearly needed. It is not known if RETIN-A appears in breast milk.    Consult your doctor before breast-feeding. Use mild soap when washing your face. Do not wash face excessively. Abrasive soaps, cleansers, medicated creams or lotions can increase skin irritation. Use other acne preparations with caution while using RETIN-A.

ADDITIONAL QUESTIONS:
   Not every question can be addressed in this FAQ page. If any additional questions remain we suggest you contact your local physician or email us .At our store we do all that we can to insure your safety.

RENOVA (tretinoin emollient cream)

FORM OF THE DRUG:
   Renova (tretinoin emollient cream 0.05%) contains the same active ingredient as Retin-A. It is a vitamin A derivative like the one naturally occurring in your body. But while Retin-A is formulated for acne-prone skin, Renova is a rich emollient cream developed specifically for treating fine lines and wrinkles, brown spots, surface roughness and stretch marks that develop on the abdominal wall in women after pregnancy.

HOW DOES RENOVA WORK?
   Renova works by binding to specific cell receptors of skin after a topical application. After the cellular receptors have been activated there is a modification in gene expression, subsequent protein synthesis and cell growth and differentiation. Thus, the epidermal cell is modified to produce a greater amount of new mature healthy skin. In clinical studies there is an enhanced production of collagen in areas of treated skin.
   Unlike over-the-counter wrinkle creams that simply exfoliate the surface layer of skin, Renova is believed to work on all layers of the skin, including the epidermis, where pigmentary changes occur and even the deeper portions of the skin where fine wrinkling is thought to begin. Medical research has shown in published articles that Renova increases collagen. Researchers believe this is one way that Renova reduces the signs of aging.

HOW EFFECTIVE IS RENOVA?

   In clinical studies looking at the efficacy of Renova 60% of patients treated for 24 weeks saw at least some decrease in fine facial wrinkling. The effect on coarse facial wrinkling, mottled hyperpigmentation, skin roughness, and laxity of the facial skin were less clear since the effect seen on each patient varied from study to study.
   A study in the Archives of Dermatology, May 1996, showed that Renova cream significantly improved the appearance of early stretch marks. Renova worked best on stretch marks that were new or enlarging, such as those that develop during pregnancy.


HOW TO USE THIS MEDICATION?
   Renova is for use on the face as directed, usually once a day at bedtime. Apply a pea-size amount of cream to clean, dry skin on the face being careful to avoid the eyes, nostrils and mouth. Wash your hands after use. Do not use this medication more often than prescribed or in larger amounts. It will not give you faster or better results but will increase the risk of side effects. Do not use on sunburn or eczema or other serious skin conditions. Effects of this medication will be gradual with most improvement seen in the first 6 months of continued therapy. If used for acne the condition may worsen at first, and then improve.

RENOVA TIMELINE:
   1-2 months: you notice smoother skin and a softer texture to your skin
   3-4 months: freckles and brown spots begin to fade. Fine lines and wrinkles begin to diminish. A rosier glow to your skin is obtained
   6 months: Benefits should be apparent with fewer wrinkles and smoother and more even toned skin

DRUG INTERACTIONS:
   Let us know on your medical history/personal profile of any nonprescription or prescription medications that you may be taking including isotretinoin, amiodarone, tetracycline or quinolone antibiotics, sulfa drugs or phenothiazines as they increase skin sensitivity to the sun. Also let us know if you are using minoxidil and any skin medication, soaps, cleansers, cosmetics, astringents or any facial products that may be drying or irritating to the skin (e.g., alcohol-containing facial products). Benzoyl peroxide should not be applied at the same time as this medication.

SIDE EFFECTS:
   You may experience mild redness or stinging, itching, burning, skin scaling, peeling and dry skin the first several weeks as your body adjusts to Renova. If any of these effects continue or become severe, discontinue use.

WARNINGS:
   Before taking this medication let us know on your medical history/personal profile if you have any pre-existing skin disorders or if you have any allergies. This medication increases your sensitivity to the sun. Limit sun exposure and avoid sun lamps. Use a sunscreen and wear protective clothing when outdoors. This medication should be used only when clearly needed during pregnancy. It is unknown if this drug is excreted into breast milk. Consult with your doctor before breast-feeding.

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